Cardiovascular: Abdominal aortic aneurysm, angina, atherosclerosis, cerebral ischemia, cerebrovascular lesion, heart block, peripheral cyanosis, phlebitis, thrombosis, and transient myocardial ischemia. Prompt treatment helps you return to your normal routine and may decrease your need for other pain medications. Sumatriptan belongs to a class of drugs known as triptans. It affects a certain natural substance serotonin that causes narrowing of blood vessels in the brain. It may also relieve pain by affecting certain nerves in the brain. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy.
Incidence in Controlled Clinical Trials of Migraine Headache: Table 4 lists adverse events that occurred in 2 large US, Phase III, placebo-controlled clinical trials in migraine patients following either a single dose of IMITREX Injection or placebo. Change in the sense of taste nasal spray. Welch KM "Drug therapy of migraine.
Imitrex spray is a serotonin 5-HT 1 receptor agonist "triptan". It works by narrowing blood vessels in the brain, which helps to relieve migraines. As you age, it is normal to experience some memory lapses. Usually, an occasional memory lapse does not mean you have a serious problem. IMITREX Injection should only be used where a clear diagnosis of migraine or cluster headache has been established. The prescriber should be aware that cluster headache patients often possess one or more predictive risk factors for coronary artery disease CAD. The plot was constructed with data from patients who either experienced relief or did not require request rescue medication within a period of 2 hours following treatment. As a consequence, the data in the plot are derived from only a subset of the 258 headaches treated rescue medication was required in 52 of the 127 placebo-treated headaches and 18 of the 131 sumatriptan-treated headaches.
If your symptoms do not improve or if they become worse, check with your doctor. Complete the What is a document? This year, I finally went to a doctor because I was tired of my migraines controlling my life. She first gave me the sumatriptan pills 10 mg at first, then 20 mg but it didn't stop the vomiting. Therefore, I couldn't keep the medicine down long enough for it to start working. So, she prescribed me the nasal spray. When I took the first dose, I was a little worried that I wouldn't take it correctly. The directions made it seem so complicated. I also didn't realize how AWFUL it would taste, so I thought I had taken too many deep breaths or something after inhaling it. It took about 2 hours before my headache was completely gone. The migraine was pretty intense, but I didn't vomit at all, which surprised me. So I think the nasal spray does work. Sure, it's not as easy as the pill, but if it stops the vomiting and completely gets rid of my migraine, I'm happy.
This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. Frequency not reported: Accommodation disorders, blindness, conjunctivitis, diplopia. Ask your doctor how long you should wait between your doses of these drugs. After taking a sumatriptan tablet, you must wait two 2 hours before taking a second tablet. Do not take more than 200 mg of sumatriptan tablets in 24 hours. Patients who are advised to self-administer IMITREX Injection in medically unsupervised situations should receive instruction on the proper use of the product from the physician or other suitably qualified health care professional prior to doing so for the first time. Your healthcare provider may change your dose. Do not change your dose without first talking with your healthcare provider. Store your medicine away from light. Injection when you start taking it and at regular checkups.
Plot. Patients taking rescue medication were censored at 15 minutes. Use sumatriptan as soon as you notice headache symptoms. Different types of medicine treat different types of headaches. The maximum single recommended adult dose of IMITREX Injection is 6 mg injected subcutaneously. Controlled clinical trials have failed to show that clear benefit is associated with the administration of a second 6-mg dose in patients who have failed to respond to a first injection. Oral administration of sumatriptan to rats prior to and throughout gestation resulted in embryofetal toxicity decreased body weight, decreased ossification, increased incidence of skeletal abnormalities. Overuse of Imitrex tablets can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor. Call your doctor for medical advice about side effects. Single doses of 5, 10, or 20 mg of Imitrex Nasal Spray administered into 1 nostril were effective for the acute treatment of migraine in adults. Therefore, do not use this medication more often or for longer than prescribed. Your doctor may ask you to take the first dose in the office. Sumatriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Teratogenicity: Term fetuses from Dutch Stride rabbits treated during organogenesis with oral sumatriptan exhibited an increased incidence of cervicothoracic vascular and skeletal abnormalities. The functional significance of these abnormalities is not known. Read the Patient Information Leaflet available from your pharmacist before you start using sumatriptan and each time you get a refill. Ask your doctor or pharmacist if you have any questions. glimepiride
IMITREX Nasal Spray sumatriptan nasal spray is generally well tolerated. Across all doses, most adverse reactions were mild and transient and did not lead to long-lasting effects. The incidence of adverse events in controlled clinical trials was not affected by gender, weight, or age of the patients; use of prophylactic medications; or presence of aura. There were insufficient data to assess the impact of race on the incidence of adverse events. Keep all away from children and pets. Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health and perhaps your life at risk. Use: For the acute treatment of migraine with or without aura. The unit contains only 1 spray. Do NOT test it before use. budecort cream price mercury drug budecort
Corneal Opacities: Sumatriptan causes corneal opacities and defects in the corneal epithelium in dogs; this raises the possibility that these changes may occur in humans. You may find that combining a triptan with a nonprescription medicine such as or helps to stop your headaches better. Talk to your doctor about this option if triptans alone aren't helping enough. If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household spoon. Some liquid products need to be shaken before each dose. Some products that contain need to be placed under the and held there before swallowing. Follow label directions carefully to get the most benefit. Other Events Observed in Association With the Administration of IMITREX Injection: In the paragraphs that follow, the frequencies of less commonly reported adverse clinical events are presented. Because the reports include events observed in open and uncontrolled studies, the role of IMITREX Injection in their causation cannot be reliably determined. Furthermore, variability associated with adverse event reporting, the terminology used to describe adverse events, etc. Sumatriptan is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes. You'll get one to three of these headaches a day. The pharmacokinetics of sumatriptan in the elderly mean age: 72 years, 2 males and 4 females and in subjects with migraine mean age: 38 years, 25 males and 155 females were similar to that in healthy male subjects mean age: 30 years. The osmolality of the injection is 291 mOsmol. In vitro studies with human microsomes suggest that sumatriptan is metabolized by MAO, predominantly the A isoenzyme. Most of a radiolabeled dose of sumatriptan excreted in the urine is the major metabolite indole acetic acid IAA or the IAA glucuronide, both of which are inactive. Follow all directions on the product package. Sumatriptan is used to treat migraines and cluster headaches. This medication should be taken only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Cardiac events that have been observed to have onset within 1 hour of sumatriptan administration include: coronary artery vasospasm, transient ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation, cardiac arrest, and death.
Five controlled clinical trials 2 single attack studies, 3 multiple attack studies evaluating oral sumatriptan 25 to 100 mg in pediatric patients aged 12 to 17 years enrolled a total of 701 adolescent migraineurs. These studies did not establish the efficacy of oral sumatriptan compated to placebo in the treatment of migraine in adolescents. Adverse events observed in these clinical trials were similar in nature to those reported in clinical trials in adults. The frequency of all adverse events in these patients appeared to be both dose- and age-dependent, with younger patients reporting events more commonly than older adolescents. Imitrex Injection is a clear, colorless to pale yellow, sterile, nonpyrogenic solution for subcutaneous injection. Drowsiness may occur during a migraine or during its treatment with this drug. Do not drive or operate machinery until you know how this drug affects you. If you have a higher risk for heart problems see Precautions your doctor may perform a heart exam before you start taking sumatriptan. Eye: Infrequent was irritation of the eye. When nothing else has worked, surgery may be an option for people who don't get a break from cluster headaches. Most of the procedures involve blocking the trigeminal nerve. miter.info finasteride
Rami Burstein, PhD, of Beth Israel Medical Center and Harvard Medical School, in a news release. Store Imitrex tablets between 36 and 86 degrees F 2 and 30 degrees C. Store away from heat, moisture, and light. Do not freeze. Do not store at temperatures above 86 degrees F 30 degrees C. Do not store in the bathroom. Keep Imitrex tablets in the case provided. Throw away expired medicine as directed by your doctor the expiration date is printed on the treatment pack. Keep Imitrex tablets out of the reach of children and away from pets. IMITREX Injection should not be given intravenously because of its potential to cause coronary vasospasm. IMITREX in their causation cannot be reliably determined. All reported events are included except those already listed, those too general to be informative, and those not reasonably associated with the use of the drug. Significant elevation in blood pressure, including hypertensive crisis with acute impairment of organ systems, has been reported on rare occasions in patients treated with 5-HT 1 agonists, including patients without a history of hypertension. Monitor blood pressure in patients treated with IMITREX. Imitrex Injection is contraindicated in patients with uncontrolled hypertension. IMITREX Injection, call your doctor immediately. If you are not sure if you have these types of migraines, ask your healthcare provider. Miscellaneous: Contusions, difficulty in walking, edema, hematoma, hypersensitivity, fever, fluid retention, lymphadenopathy, overdose, speech disturbance, swelling of extremities, swelling of face, and voice disturbances. To use Imitrex spray, remove the nasal spray unit from the plastic pack. motilium stock price forecast
Medicines are sometimes prescribed for purposes other than those listed in Patient Information leaflets. Do not use IMITREX for a condition for which it was not prescribed. Do not give IMITREX to other people, even if they have the same symptoms you have. It may harm them. Use: For the acute treatment of cluster headache. Medicines are sometimes prescribed for purposes other than those listed in Patient Information leaflets. Do not use Imitrex for a condition for which it was not prescribed. Do not give Imitrex to other people, even if they have the same symptoms you have. It may harm them. Metabolism: In vitro studies with human microsomes suggest that sumatriptan is metabolized by MAO, predominantly the A isoenzyme. Most of a radiolabeled dose of sumatriptan excreted in the urine is the major metabolite indole acetic acid IAA or the IAA glucuronide, both of which are inactive. It is best to take a dose of Imitrex tablets as soon as you notice symptoms of a migraine attack. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.
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Do not consider Communities as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. cheapest oxybutynin order now shop
At what time of day do the headaches happen? Cluster headaches don't make you queasy or throw up. But it's possible for someone with cluster headaches to also get migraines, which can have those symptoms. Franceschini R, Cataldi A, Garibaldi A, Cianciosi P, Scordamaglia A, Barreca T, Rolandi E "The effects of sumatriptan on pituitary secretion in man.
WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. geodon
This drug passes into breast milk and may have undesirable effects on a nursing infant. Avoid breastfeeding for at least 12 hours after using sumatriptan. Consult your doctor before breast-feeding. Ways to manage your time. Drink plenty of fluids as directed by your doctor to prevent and tell your doctor right away if you have a change in the amount of urine. Ask your doctor or pharmacist about using this product safely. Imitrex tablets are not approved for use in CHILDREN younger than 18 years old. Talk with the doctor. insulin